A constrained maximum likelihood approach to evaluate the impact of dose metric on cancer risk assessment: application to β-chloroprene.
Identifieur interne : 004320 ( Main/Exploration ); précédent : 004319; suivant : 004321A constrained maximum likelihood approach to evaluate the impact of dose metric on cancer risk assessment: application to β-chloroprene.
Auteurs : B C Allen [États-Unis] ; C. Van Landingham [États-Unis] ; Y. Yang [États-Unis] ; A O Youk [États-Unis] ; G M Marsh [États-Unis] ; N. Esmen [États-Unis] ; P R Gentry [États-Unis] ; H J Clewell [États-Unis] ; M W Himmelstein [États-Unis]Source :
- Regulatory toxicology and pharmacology : RTP [ 1096-0295 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Cancérogènes (administration et posologie), Cancérogènes (pharmacocinétique), Cancérogènes (toxicité), Chloroprène (administration et posologie), Chloroprène (pharmacocinétique), Chloroprène (toxicité), Femelle, Fonctions de vraisemblance, Humains, Mâle, Rats, Rats de lignée F344, Relation dose-effet des médicaments, Souris, Spécificité d'espèce, Tumeurs (), Tumeurs (épidémiologie), Évaluation des risques ().
- MESH :
- administration et posologie : Cancérogènes, Chloroprène.
- pharmacocinétique : Cancérogènes, Chloroprène.
- toxicité : Cancérogènes, Chloroprène.
- épidémiologie : Tumeurs.
- Animaux, Femelle, Fonctions de vraisemblance, Humains, Mâle, Rats, Rats de lignée F344, Relation dose-effet des médicaments, Souris, Spécificité d'espèce, Tumeurs, Évaluation des risques.
English descriptors
- KwdEn :
- Animals, Carcinogens (administration & dosage), Carcinogens (pharmacokinetics), Carcinogens (toxicity), Chloroprene (administration & dosage), Chloroprene (pharmacokinetics), Chloroprene (toxicity), Dose-Response Relationship, Drug, Female, Humans, Likelihood Functions, Male, Mice, Neoplasms (chemically induced), Neoplasms (epidemiology), Rats, Rats, Inbred F344, Risk Assessment (methods), Species Specificity.
- MESH :
- chemical , administration & dosage : Carcinogens, Chloroprene.
- chemical , pharmacokinetics : Carcinogens, Chloroprene.
- chemical , toxicity : Carcinogens, Chloroprene.
- chemically induced : Neoplasms.
- epidemiology : Neoplasms.
- methods : Risk Assessment.
- Animals, Dose-Response Relationship, Drug, Female, Humans, Likelihood Functions, Male, Mice, Rats, Rats, Inbred F344, Species Specificity.
Abstract
β-Chloroprene (2-chloro-1,3-butadiene, CD) is used in the manufacture of polychloroprene rubber. Chronic inhalation studies have demonstrated that CD is carcinogenic in B6C3F1 mice and Fischer 344 rats. However, epidemiological studies do not provide compelling evidence for an increased risk of mortality from total cancers of the lung. Differences between the responses observed in animals and humans may be related to differences in toxicokinetics, the metabolism and detoxification of potentially active metabolites, as well as species differences in sensitivity. The purpose of this study was to develop and apply a novel method that combines the results from available physiologically based kinetic (PBK) models for chloroprene with a statistical maximum likelihood approach to test commonality of low-dose risk across species. This method allows for the combined evaluation of human and animal cancer study results to evaluate the difference between predicted risks using both external and internal dose metrics. The method applied to mouse and human CD data supports the hypothesis that a PBK-based metric reconciles the differences in mouse and human low-dose risk estimates and further suggests that, after PBK metric exposure adjustment, humans are equally or less sensitive than mice to low levels of CD exposure.
DOI: 10.1016/j.yrtph.2014.07.001
PubMed: 25010378
Affiliations:
- États-Unis
- Caroline du Nord, Delaware, Illinois, Louisiane, Pennsylvanie
- Chicago, Pittsburgh
- Université de Pittsburgh, Université de l'Illinois à Chicago
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Le document en format XML
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Electronic address: gmarsh@pitt.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Occupational Biostatistics and Epidemiology, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, 130 De Soto St., Pittsburgh, PA 15261</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Esmen, N" sort="Esmen, N" uniqKey="Esmen N" first="N" last="Esmen">N. Esmen</name><affiliation wicri:level="4"><nlm:affiliation>Occupational and Environmental Health Sciences, School of Public Health, University of Illinois at Chicago, 2121 West Taylor Street, Chicago, IL 60622, United States. 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Electronic address: rgentry@environcorp.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>ENVIRON International Corporation, 1900 North 18th St. Monroe, LA 71201</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Clewell, H J" sort="Clewell, H J" uniqKey="Clewell H" first="H J" last="Clewell">H J Clewell</name><affiliation wicri:level="2"><nlm:affiliation>Center for Human Health Assessment, The Hamner Institutes for Health Sciences, 6 Davis Drive (PO Box 12137), Research Triangle Park, NC 27703, United States. Electronic address: hclewell@thehamner.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Health Assessment, The Hamner Institutes for Health Sciences, 6 Davis Drive (PO Box 12137), Research Triangle Park, NC 27703</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Himmelstein, M W" sort="Himmelstein, M W" uniqKey="Himmelstein M" first="M W" last="Himmelstein">M W Himmelstein</name><affiliation wicri:level="2"><nlm:affiliation>DuPont Haskell Global Centers for Health & Environmental Sciences, PO Box 30, 1090 Elkton Road, Newark, DE 19711, United States. Electronic address: matthew.w.himmelstein@dupont.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>DuPont Haskell Global Centers for Health & Environmental Sciences, PO Box 30, 1090 Elkton Road, Newark, DE 19711</wicri:regionArea><placeName><region type="state">Delaware</region></placeName></affiliation></author></analytic><series><title level="j">Regulatory toxicology and pharmacology : RTP</title><idno type="eISSN">1096-0295</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Carcinogens (administration & dosage)</term><term>Carcinogens (pharmacokinetics)</term><term>Carcinogens (toxicity)</term><term>Chloroprene (administration & dosage)</term><term>Chloroprene (pharmacokinetics)</term><term>Chloroprene (toxicity)</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Humans</term><term>Likelihood Functions</term><term>Male</term><term>Mice</term><term>Neoplasms (chemically induced)</term><term>Neoplasms (epidemiology)</term><term>Rats</term><term>Rats, Inbred F344</term><term>Risk Assessment (methods)</term><term>Species Specificity</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cancérogènes (administration et posologie)</term><term>Cancérogènes (pharmacocinétique)</term><term>Cancérogènes (toxicité)</term><term>Chloroprène (administration et posologie)</term><term>Chloroprène (pharmacocinétique)</term><term>Chloroprène (toxicité)</term><term>Femelle</term><term>Fonctions de vraisemblance</term><term>Humains</term><term>Mâle</term><term>Rats</term><term>Rats de lignée F344</term><term>Relation dose-effet des médicaments</term><term>Souris</term><term>Spécificité d'espèce</term><term>Tumeurs ()</term><term>Tumeurs (épidémiologie)</term><term>Évaluation des risques ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Carcinogens</term><term>Chloroprene</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Carcinogens</term><term>Chloroprene</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Carcinogens</term><term>Chloroprene</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Cancérogènes</term><term>Chloroprène</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Risk Assessment</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Cancérogènes</term><term>Chloroprène</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Cancérogènes</term><term>Chloroprène</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Tumeurs</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Humans</term><term>Likelihood Functions</term><term>Male</term><term>Mice</term><term>Rats</term><term>Rats, Inbred F344</term><term>Species Specificity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Fonctions de vraisemblance</term><term>Humains</term><term>Mâle</term><term>Rats</term><term>Rats de lignée F344</term><term>Relation dose-effet des médicaments</term><term>Souris</term><term>Spécificité d'espèce</term><term>Tumeurs</term><term>Évaluation des risques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">β-Chloroprene (2-chloro-1,3-butadiene, CD) is used in the manufacture of polychloroprene rubber. Chronic inhalation studies have demonstrated that CD is carcinogenic in B6C3F1 mice and Fischer 344 rats. However, epidemiological studies do not provide compelling evidence for an increased risk of mortality from total cancers of the lung. Differences between the responses observed in animals and humans may be related to differences in toxicokinetics, the metabolism and detoxification of potentially active metabolites, as well as species differences in sensitivity. The purpose of this study was to develop and apply a novel method that combines the results from available physiologically based kinetic (PBK) models for chloroprene with a statistical maximum likelihood approach to test commonality of low-dose risk across species. This method allows for the combined evaluation of human and animal cancer study results to evaluate the difference between predicted risks using both external and internal dose metrics. The method applied to mouse and human CD data supports the hypothesis that a PBK-based metric reconciles the differences in mouse and human low-dose risk estimates and further suggests that, after PBK metric exposure adjustment, humans are equally or less sensitive than mice to low levels of CD exposure.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Delaware</li><li>Illinois</li><li>Louisiane</li><li>Pennsylvanie</li></region><settlement><li>Chicago</li><li>Pittsburgh</li></settlement><orgName><li>Université de Pittsburgh</li><li>Université de l'Illinois à Chicago</li></orgName></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Allen, B C" sort="Allen, B C" uniqKey="Allen B" first="B C" last="Allen">B C Allen</name></region><name sortKey="Clewell, H J" sort="Clewell, H J" uniqKey="Clewell H" first="H J" last="Clewell">H J Clewell</name><name sortKey="Esmen, N" sort="Esmen, N" uniqKey="Esmen N" first="N" last="Esmen">N. Esmen</name><name sortKey="Gentry, P R" sort="Gentry, P R" uniqKey="Gentry P" first="P R" last="Gentry">P R Gentry</name><name sortKey="Himmelstein, M W" sort="Himmelstein, M W" uniqKey="Himmelstein M" first="M W" last="Himmelstein">M W Himmelstein</name><name sortKey="Marsh, G M" sort="Marsh, G M" uniqKey="Marsh G" first="G M" last="Marsh">G M Marsh</name><name sortKey="Van Landingham, C" sort="Van Landingham, C" uniqKey="Van Landingham C" first="C" last="Van Landingham">C. Van Landingham</name><name sortKey="Yang, Y" sort="Yang, Y" uniqKey="Yang Y" first="Y" last="Yang">Y. Yang</name><name sortKey="Youk, A O" sort="Youk, A O" uniqKey="Youk A" first="A O" last="Youk">A O Youk</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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